Weight loss,prescribed bya real clinic.
Compounded semaglutide from $199/mo and tirzepatide at $329/mo — prescribed by a licensed provider if treatment is appropriate for you, cold-shipped monthly with supplies included.
Available in 51 states · Free medical review · Full refund if a provider doesn't approve treatment
The program
From intake to ongoing care
The same medical process as an in-person weight-management visit — without the appointment. A licensed provider makes every prescribing decision, start to finish.
015-minute intake
Check eligibility, pick a plan, and complete a structured health questionnaire online. No appointment, no video call, no waiting room.
02Provider review
A licensed provider reviews your intake, typically within 24–48 hours, and decides whether treatment is appropriate. If it isn’t, you get a full refund.
03Cold-shipped monthly
Medication ships from a licensed U.S. pharmacy in cold-chain packaging, injection supplies included, tracking on every box.
04Titration support
Doses start low and step up gradually as tolerated. Your provider sets every adjustment on the standard titration schedule — never on autopilot.
05Ongoing care
Message your care team any time. Side-effect questions, dose concerns, plan changes — a real clinic stays on the other end.
Transparent pricing
Treatment plans
One flat monthly price per plan — medication, injection supplies, cold shipping, medical review, and provider follow-up included. No membership fees. Your provider decides which medication and dose, if any, is appropriate.
The science
How the medications work
Both are once-weekly injections built on incretin hormones — the signals your gut sends the brain after eating. Here is the mechanism, without the mystique.
GLP-1 receptor agonist
Compounded Semaglutide
The most-prescribed GLP-1 for weight loss
GLP-1 receptor agonist
Semaglutide mimics GLP-1, a hormone your gut releases after eating. It signals fullness to the brain, reduces appetite, and slows how quickly food leaves the stomach — so smaller meals satisfy you for longer.
Gradual weekly titration
Treatment starts at a low weekly dose and increases stepwise over several months as tolerated. Titrating slowly is how providers minimize the digestive side effects that come from raising the dose too fast.
Works with lifestyle change
GLP-1 therapy is studied and prescribed alongside a reduced-calorie diet and increased activity. The medication makes the behavior change sustainable — it does not replace it.
Dual GIP + GLP-1 receptor agonist
Compounded Tirzepatide
Dual-action GIP + GLP-1 — one price at every dose
Dual GIP + GLP-1 receptor agonist
Tirzepatide activates both the GLP-1 receptor (appetite, fullness, gastric emptying) and the GIP receptor (a second incretin pathway involved in how the body handles nutrients). The dual mechanism is why its trial results are the strongest published in the class.
Compounded with metabolic cofactors
Our pharmacy compounds tirzepatide with vitamin B12, Glycine, B6, and L-Carnitine based on patient medical needs — cofactors involved in energy metabolism commonly paired with GLP-1 therapy.
Flat pricing across titration
Tirzepatide titrates from low starting doses to higher maintenance doses over several months. At Affinity the monthly price does not change as your provider raises your dose.
Side by side
Semaglutide vs. tirzepatide
Both reduce appetite with a once-weekly injection. The honest differences, so you and your provider can pick the right starting point.
GLP-1
Semaglutide
How it works
GLP-1 receptor agonist — reduces appetite and slows stomach emptying
Results in clinical trials of the branded versions
Average weight loss of about 15% of body weight over 68 weeks (STEP 1 trial)
Injection schedule
Once weekly
Monthly price at Affinity
From $199/mo
Included in the compound
Semaglutide
Dual GIP + GLP-1
Tirzepatide
How it works
Dual GIP + GLP-1 receptor agonist — acts on two hunger-regulating pathways
Results in clinical trials of the branded versions
Average weight loss of up to about 21% of body weight over 72 weeks (SURMOUNT-1 trial, highest dose)
Injection schedule
Once weekly
Monthly price at Affinity
$329/mo at any dose
Included in the compound
Tirzepatide + B12, Glycine, B6, L-Carnitine
Swipe to compare
Trial figures describe the FDA-approved branded medications studied at their full maintenance doses alongside diet and exercise — individual results vary and no outcome is guaranteed. Compounded medications are not FDA-approved. A licensed provider decides which medication, if any, is appropriate for you.
Grounded in published research
What the trials actually showed
These figures come from the landmark trials of the FDA-approved branded versions, taken at full maintenance doses alongside diet and exercise. We cite them because they are the best evidence in the class — not as a promise about your result.
~15% average body-weight loss
STEP 1In the STEP 1 trial of the FDA-approved branded version (2.4 mg weekly alongside diet and exercise), adults lost an average of about 15% of body weight over 68 weeks. Individual results vary and no outcome is guaranteed; compounded semaglutide is a separate, non-FDA-approved preparation.
Wilding et al., NEJM (2021) — STEP 1
Up to ~21% average body-weight loss
SURMOUNT-1In the SURMOUNT-1 trial of the FDA-approved branded version (highest dose alongside diet and exercise), adults lost an average of up to about 21% of body weight over 72 weeks. Individual results vary and no outcome is guaranteed; compounded tirzepatide is a separate, non-FDA-approved preparation.
Jastreboff et al., NEJM (2022) — SURMOUNT-1
What to honestly expect
The first weeks
Appetite change usually comes first, at low starter doses. Mild nausea early on is the most common side effect and typically eases as your body adjusts.
Months 2–6
Doses titrate up gradually as tolerated. Trial-average results took a year or more of consistent weekly dosing — this is a long-term therapy, not a quick fix.
Individual results vary
No amount of weight loss is guaranteed, and compounded medications are not FDA-approved. The medication supports diet and activity change — it does not replace it.
The medical review
A licensed provider decides —
not an algorithm
Affinity Direct is the online arm of a clinic network that has treated patients in person since 2012. The intake you complete is reviewed the same way it would be in one of our exam rooms — by a licensed clinician who can say yes, ask for more information, or say no.
Licensed in your state
The provider who reviews your intake holds an active license in the state where you live — that’s what makes the prescription legitimate.
A real medical decision
Your full intake — history, medications, contraindications — is reviewed by a clinician. Approval is never automatic, and “no” is a real answer.
Typically 24–48 hours
Most reviews complete within two days. If the provider needs more detail, they may request a quick video visit at no extra cost.
Declined = full refund
If treatment isn’t appropriate for you, the provider declines it and we refund the entire amount. You never pay for medication you can’t receive.
Before you pay
Who qualifies —
honestly
GLP-1 therapy isn't for everyone, and we won't pretend it is. Providers generally consider treatment for adults who meet the standard medical criteria below. Our eligibility check screens you before you pay — and a licensed provider always makes the final decision after reviewing your full health intake.
BMI 30 or higher
Meets the standard criteria providers use for GLP-1 weight-loss therapy on its own.
BMI 27–29.9 with a weight-related condition
Such as high blood pressure, type 2 diabetes or prediabetes, high cholesterol, or sleep apnea.
BMI below 27
GLP-1 therapy generally isn’t appropriate — our eligibility check will tell you before you pay, not after.
Why Affinity
Not a weight-loss app.
A clinic.
Affinity Direct is the online arm of Affinity Whole Health — established 2012, with 4 Midwest clinic locations and 10,000+ patients. LegitScript certified, HIPAA compliant, and staffed by licensed providers.
Questions, answered
Weight loss — common questions
See if you qualify.
The eligibility check takes about two minutes and is free. You only pay if you qualify and choose a plan — and only keep paying if a provider approves treatment.
Full refund if a licensed provider does not approve your treatment
Medical Disclosure
Important safety information: Compounded semaglutide and compounded tirzepatide are prepared by licensed U.S. compounding pharmacies and are not FDA-approved. The FDA does not review compounded medications for safety, effectiveness, or quality before they are dispensed. Prescription weight-loss medication is only available if a licensed provider determines it is appropriate for you after reviewing your health intake. Individual results vary and no amount of weight loss is guaranteed. GLP-1 medications should be used alongside a reduced-calorie diet and increased physical activity.