NAD+
Cellular Energy & Longevity
Energy · Cognitive clarity · Longevity
Starting at $149 · Syringes & swabs included · Provider review free · Shipping free.
How NAD+ Works
NAD+ declines ~50% by age 50. Subcutaneous NAD+ bypasses oral degradation to directly replenish cellular NAD+ pools — the cofactor behind every energy-producing reaction.
Subcutaneous injection — a small needle into the fatty tissue beneath the skin. Bypasses oral degradation for near-complete bioavailability. Given at home with step-by-step video guidance and education — no clinic visits required.
Key Benefits
- Boosts cellular energy (ATP)
- Sharpens mental clarity and focus
- Reduces fatigue
- Supports mitochondrial function
- Activates longevity pathways (sirtuins)
- Supports DNA repair
Ideal For
- Mental performance
- Energy optimization
- Anti-aging protocols
- Post-illness recovery
The Science Behind NAD+
Sirtuin Activation
NAD+ is the essential cofactor for sirtuin enzymes (SIRT1–7) — the longevity proteins that regulate DNA repair, inflammation, and metabolic homeostasis. Sirtuins require NAD+ to function.
Mitochondrial Function
NAD+ is central to the electron transport chain and ATP synthesis. Declining NAD+ with age is directly associated with decreased mitochondrial efficiency and the energy decline characteristic of aging.
Real pharmacy medication —
not gray-market peptides
Your NAD+ is a genuine prescription medication, compounded for you by a licensed U.S. pharmacy and dispensed only after a provider approves it. That is a different world from the “research only” peptides sold online with no provider, no pharmacy, and no testing behind them.
Compounded by a licensed U.S. pharmacy
Every order is prepared for you individually by a state-licensed compounding pharmacy under a valid prescription — and those pharmacies operate under the oversight of state boards of pharmacy.
Made to USP sterility standards
Our injectables are compounded to USP <797> — the national standard for sterile preparations that helps protect against contamination, sub-potency, and dosing errors.
Tested for identity, strength & purity
Each batch is verified against established USP quality standards, and we can provide a Certificate of Analysis (COA) on request — so you know exactly what is in the vial.
A real provider behind every vial
A licensed Affinity provider reviews your health history and writes the prescription. Products labeled “research use only” or “not for human use” have none of that — and the FDA has taken action against sellers marketing peptides that way.
Straight talk: compounded medications like these are not FDA-approved, which means the FDA does not review them before they are dispensed. What they do have is a licensed pharmacy, a valid prescription, sterile-compounding standards, and batch testing standing behind them — the safeguards an unregulated vial bought online simply does not have.
How our NAD+ pricing compares
Compared on injectable (subcutaneous) NAD+ at comparable at-home dosing. Figures below are the est. cost per month.
Affinity is the lowest-cost option in every category — and the only one without a subscription or paid membership.
Est. cost per month shown for comparison. Other providers' prices are their publicly listed rates as of June 2026 and may require a paid subscription or membership as noted — see each provider's site for current pricing. Affinity Direct is a one-time purchase or refill, with provider review always free.
NAD+ — Common Questions
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell — essential to energy metabolism, DNA repair, and sirtuin activation (longevity pathways). NAD+ declines approximately 50% by age 50 due to increased consumption by stress-response enzymes (PARPs, CD38) and decreased synthesis.
NMN and NR are NAD+ precursors that must be converted by the body — and much is lost in digestion. Subcutaneous NAD+ bypasses oral degradation and directly replenishes cellular NAD+ pools, providing more reliable and measurable elevation of NAD+ levels.
Your provider will determine the appropriate starting dose. Common protocols include 100 mg 2× weekly for faster results, or 50 mg 1× weekly for a gentler start. Dosing is adjusted based on your response and tolerance.
NAD+ injections may cause mild transient flushing, warmth, or injection site sensitivity at higher doses. These effects are dose-dependent and typically resolve within minutes. Starting at a lower dose and titrating up reduces early reactions.
Supply duration depends on your prescribed dose. At 100 mg 2× weekly, a 10 mL vial (100 mg/mL concentration) provides approximately 5 weeks of supply. Your dosing protocol determines the cadence between refills.
NAD+ is most impactful for adults experiencing energy decline, cognitive fogginess, or those focused on longevity and healthy aging. It's also used in post-illness recovery protocols and by high-performers seeking cognitive and metabolic optimization.
Side effects are usually mild and dose-related — injecting slowly is the simplest way to avoid them. The most common are temporary flushing or warmth, mild nausea, a brief headache, or tenderness at the injection site. Less commonly, people notice short-lived muscle aches or fatigue. Starting at a gentle dose and pushing slowly keeps almost everyone comfortable. Reach out any time something doesn't feel right.
NAD+ injections aren't appropriate for anyone with active cancer or a history of cancer, severe liver or kidney disease, or for anyone who is pregnant or breastfeeding. Your Affinity provider reviews your full health history during intake and won't prescribe it if it isn't safe for you.
Start NAD+ Today.
Provider review free. Shipping free. Full refund if treatment is not approved.
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These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. Compounded medications require a valid prescription from a licensed provider. For investigational/wellness use only.